Influence of the amount of antigen and the interval on the secondary reaction |
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Authors: | M Jílek J Šterzl |
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Institution: | (1) Department of Immunology, Institute of Microbiology, Czechoslovak Academy of Sciences, Prague 4 |
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Abstract: | The course of the revaccination reaction in mice immunized with different doses of sheep red blood cells was determined at
different intervals after the primary stimulus. The maximum level of haemagglutinating antibodies in the secondary reaction
was found after a high primary and secondary antigenic stimulus. On the contrary, if the level of haemolytic antibodies was
determined, the higher was the primary antigenic stimulus, the lower was the secondary antibody response. Differences between
haemagglutinins and haemolytic antibodies were also manifested in the earlier onset of the maximum haemolytic secondary reaction
(five months after the first dose of antigen); the maximum haemagglutination response was not attained until eight months
after the primary dose of antigen. The results comfirm that the basis of preparation for the secondary reaction is proliferation
of immunologically activated Y cells; differences in the haemolytic and haemagglutination response are related to differences
in the character of the antigenic determinants of sheep red cells. |
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