Inducible and constitutive heat shock gene expression responds to modification of Hsp70 copy number in Drosophila melanogaster but does not compensate for loss of thermotolerance in Hsp70 null flies |
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| Authors: | Brian R Bettencourt Catherine C Hogan Mario Nimali and Brian W Drohan |
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| Institution: | (1) Department of Biological Sciences, University of Massachusetts Lowell, 1 University Avenue, Lowell, MA 01854, USA;(2) Department of Computer Science, University of Massachusetts Lowell, 1 University Avenue, Lowell, MA 01854, USA |
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| Abstract: | Background The heat shock protein Hsp70 promotes inducible thermotolerance in nearly every organism examined to date. Hsp70 interacts
with a network of other stress-response proteins, and dissecting the relative roles of these interactions in causing thermotolerance
remains difficult. Here we examine the effect of Hsp70 gene copy number modification on thermotolerance and the expression of multiple stress-response genes in Drosophila melanogaster, to determine which genes may represent mechanisms of stress tolerance independent of Hsp70. |
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