Improved accuracy of multiple ncRNA alignment by incorporating structural information into a MAFFT-based framework |
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Authors: | Kazutaka Katoh Hiroyuki Toh |
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Institution: | (1) Digital Medicine Initiative, Kyushu University, Fukuoka 812-8582, Japan;(2) Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan |
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Abstract: | Background Structural alignment of RNAs is becoming important, since the discovery of functional non-coding RNAs (ncRNAs). Recent studies,
mainly based on various approximations of the Sankoff algorithm, have resulted in considerable improvement in the accuracy
of pairwise structural alignment. In contrast, for the cases with more than two sequences, the practical merit of structural
alignment remains unclear as compared to traditional sequence-based methods, although the importance of multiple structural
alignment is widely recognized. |
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Keywords: | |
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