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Pre-existing Functional Heterogeneity of Tumorigenic Compartment as the Origin of Chemoresistance in Pancreatic Tumors
Authors:Sahil Seth  Chieh-Yuan Li  I-Lin Ho  Denise Corti  Sara Loponte  Luigi Sapio  Edoardo Del Poggetto  Er-Yen Yen  Frederick Scott Robinson  Michael Peoples  Tatiana Karpinets  Angela Kay Deem  Tapsi Kumar  Xingzhi Song  Shan Jiang  Ya’an Kang  Jason Fleming  Michael Kim  Andrea Viale
Institution:1. Center for Co-Clinical Trials, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;2. UTHealth Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;3. Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;4. Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;5. Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;6. Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL, USA;7. Sheikh Ahmed Center for Pancreatic Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;8. Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Abstract:
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  • Keywords:tumor heterogeneity  functional heterogeneity  lineage tracing  clonal dynamics  clonal isolation  pancreatic cancer  drug resistance  subclonal gene signature  prognostic stratification
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