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Patient Adipose Stem Cell-Derived Adipocytes Reveal Genetic Variation that Predicts Antidiabetic Drug Response
Authors:Wenxiang Hu  Chunjie Jiang  Dongyin Guan  Pieterjan Dierickx  Rong Zhang  Arden Moscati  Girish N Nadkarni  David J Steger  Ruth JF Loos  Cheng Hu  Weiping Jia  Raymond E Soccio  Mitchell A Lazar
Institution:1. Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA;2. Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA;3. Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China;4. Institute for Metabolic Disease, Fengxian Central Hospital Affiliated to Southern Medical University, Shanghai 201499, China;5. The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;6. The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Abstract:
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  • Keywords:adipose stem cell  adipocytes  PPARγ  antidiabetic drug  rosiglitazone  genetic variation  drug response  ABCA1
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