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Deterministic Somatic Cell Reprogramming Involves Continuous Transcriptional Changes Governed by Myc and Epigenetic-Driven Modules
Authors:Asaf Zviran  Nofar Mor  Yoach Rais  Hila Gingold  Shani Peles  Elad Chomsky  Sergey Viukov  Jason D. Buenrostro  Roberta Scognamiglio  Leehee Weinberger  Yair S. Manor  Vladislav Krupalnik  Mirie Zerbib  Hadas Hezroni  Diego Adhemar Jaitin  David Larastiaso  Shlomit Gilad  Sima Benjamin  Jacob H. Hanna
Affiliation:1. Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 761001, Israel;2. New York Genome Center, New York, NY, USA;3. Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel;4. Department of Computer Science, Weizmann Institute of Science, Rehovot, Israel;5. Broad Institute of MIT and Harvard, Cambridge, MA, USA;6. Harvard Society of Fellows, Harvard University, Cambridge, MA, USA;7. Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany;8. Department of Immunology, Weizmann Institute of Science, Rehovot, Israel;9. Israel National Center for Personalized Medicine (G-INCPM), Weizmann Institute of Science, Rehovot, Israel;10. Department of Gastroenterology, Rambam Hospital, Haifa, Israel;11. Department of Pediatrics, Rambam Hospital, Haifa, Israel;12. Department of Molecular and Cell Biology, Weizmann Institute of Science, Rehovot, Israel;13. Department of Genetics, Stanford University, Palo Alto, CA, USA;14. Chan Zuckerberg Biohub, San Francisco, CA, USA
Abstract:
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  • Keywords:Mbd3  NuRD  Gatad2a  iPSC  deterministic reprogramming  pluripotency  epigenetics  Myc  epigenomics
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