Hepatic endothelial lipase activity in neonatal rat liver |
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Authors: | Ferran Burgaya Julia Peinado Miquel Llobera Ignasi Ramirez |
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Institution: | (1) Unitat de Bioquímica i Biologia Molecular B, Departament de Bioquímica i Fisiologia, Facultat de Biologia, Universitat de Barcelona, Avda Diagonal 645, 08071 Barcelona, Spain;(2) Present address: Departament de Genètica, Facultat de Biologia, Universitat de Barcelona, Avda Diagonal 645, 08071 Barcelona, Spain |
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Abstract: | Hepatic endothelial lipase (HEL) activity is as high in the neonatal (1-day old) rat liver as in adults. Most of the HEL activity is located at the capillaries since 75% of the total activity is released by heparin or collagenase perfusion. The residual activity (non-releasable) is located in hepatocytes and not in hemopoietic cells, which are the major cell type in neonatal liver. Per mg of protein, the HEL activity is 50% higher in neonatal than in adult hepatocytes. We suggest that neonatal hepatocytes have an increased capacity to synthesize and secrete HEL activity, so maintaining a high activity in the whole organ. it might contribute to the hepatic uptake of cholesterol from circulating lipoproteins, in a period in which endogenous cholesterol synthesis is known to be inhibited in the liver. |
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Keywords: | lipase liver heparin perfusion hepatocytes hemopoietic cells neonate rat |
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