Adriamycin and daunomycin induce interstrand DNA crosslinks in HeLa S3 cells |
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| Authors: | Jerzy Konopa |
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| Institution: | Department of Pharmaceutical Technology and Biochemistry, Technical University, 80-952 Gdansk, Poland |
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| Abstract: | By using a new mild procedure for detecting DNA crosslinks it has been shown that adriamycin and daunomycin are able to form interstrand DNA crosslinks in HeLa cells. This effect seems to be preceded by transformation of the parent antibiotics in the cell to active forms. In addition, interstrand DNA crosslinks formed by adriamycin and daunomycin were found to be temperature- and alkali-labile. |
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| Keywords: | RF renaturable fraction of DNA ΔRF increase in renaturable fraction of DNA |
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