Dual effects of calcium on the oxidation of fatty acids to ketone bodies in liver mitochondria |
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| Authors: | Joseph A Ontko Donna Jean Westbrook |
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| Institution: | 1. Cardiovascular Research Laboratory, Oklahoma Medical Research Foundation, University of Oklahoma College of Medicine, Oklahoma City, OK 73104, USA;2. Department of Biochemistry and Molecular Biology, University of Oklahoma College of Medicine, Oklahoma City, OK 73104, USA |
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| Abstract: | The addition of calcium ions (Ca2+) to rat liver mitochondria, under conditions of rapid accumulation of 10–40 nmol Ca2+/mg protein, inhibited the oxidation of long and medium chain fatty acids to ketone bodies, whereas higher quantities of Ca2+ activated the process. The mitochondrial NADH:NAD ratio exhibited corresponding depression and elevation. Both inhibitory and stimulatory actions of Ca2+ were operative in liver mitochondria from fed and fasted rats and appear to be localized in the mitochondrial inner membranematrix region. These observations may signify involvement of Ca2+ in the regulation of fatty acid oxidation and ketogenesis. |
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