Closed circular DNA as a probe for protein-induced structural changes. |
| |
Authors: | J H White R M Gallo W R Bauer |
| |
Affiliation: | Department of Mathematics, University of California, Los Angeles 90024. |
| |
Abstract: | Biological systems are replete with examples of DNA formed into a closed loop structure, either alone or in close association with proteins. Such closed circular DNA molecules are subject to a topological constraint that modifies, often in a major way, the structure and reactivity of the DNA. The topological constraint also permits closed circular DNAs to be used as analytical tools to learn about the structure of DNA-protein complexes. |
| |
Keywords: | |
|
|