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Closed circular DNA as a probe for protein-induced structural changes.
Authors:J H White  R M Gallo  W R Bauer
Affiliation:Department of Mathematics, University of California, Los Angeles 90024.
Abstract:Biological systems are replete with examples of DNA formed into a closed loop structure, either alone or in close association with proteins. Such closed circular DNA molecules are subject to a topological constraint that modifies, often in a major way, the structure and reactivity of the DNA. The topological constraint also permits closed circular DNAs to be used as analytical tools to learn about the structure of DNA-protein complexes.
Keywords:
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