| NO对家兔Oddi括约肌肌电活动和血压的影响 |
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| 作者姓名： | Zhang M Ding CH Zhang LW Yang SY |
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| 作者单位： | 1. 河北医科大学病理生理学教研室,石家庄,050017
2. 河北医科大学病理生理学门诊部,石家庄,050017 |
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| 基金项目： | 河北省自然科学基金!394295 |
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| 摘 要： | 应用３２只家兔观察一氧氮对Ｏｄｄｉ括约肌肌电和血压的影响。静脉注射ＮＯ合酶抑制剂Ｎ＾Ｇ－硝基－Ｌ－精氨酸,可见ＳＯ肌电振幅增大和血压升高,Ｌ－ＮＮＡ所致的肌电活动增强可Ｌ－精氨酸反转。
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| 关 键 词： | 一氧化氮 Oddi括约肌 肌电 血压 家兔 |
| 修稿时间： | 1997年10月31 |
Effect of nitric oxide on the myoelectric activity of sphincter of Oddi and arterial blood pressure of rabbit |
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| Zhang M,Ding CH,Zhang LW,Yang SY.Effect of nitric oxide on the myoelectric activity of sphincter of Oddi and arterial blood pressure of rabbit[J].Acta Physiologica Sinica,1998,50(6):618-622. |
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| Authors: | Zhang M Ding C H Zhang L W Yang S Y |
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| Institution: | Department of Pathophysiology and Outpatient Department, Hebei Medical University, Shijiazhuang 050017. |
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| Abstract: | Thirty-two rabbits were used to investigate the effect of nitric oxide (NO) on the myoelectric activity of the sphincter of Oddi (SO) and arterial blood pressure. Intravenous infusion of NG-nitro-L-arginine(L-NNS), an inhibitor of nitric cxide synthase (NOS) ) caused increase in SO phasic wave amplitude and arterial blood pressure. The increase in SO phasic wave amplitude by infusion of L-NNA was reversed by L-arginine,but arterial blood pressure remained at a high level. It was observed that SO phasic wave amplitude, frequency and arterial blood pressure were significantly decreased by intravenously infusion of sodium nitroprusside (SNP), a substance producing NO. These Observations suggest that (1) NO inhibits the resting activity of SO and modulates relaxation of vascular smooth muscle; (2) different tissues show different responses to L-NNA and L-arginine. |
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| Keywords: | sphincter of Oddi myoelectric activity nitric oxide arterial blood pressure rabbit |
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