Biological activity ofTreponema hyodysenteriae hemolysin |
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| Authors: | Samir A Saheb Real Lallier Luc Massicotte Louis Lafleur Suzanne Lemieux |
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| Institution: | (1) Centre de Recherche en Bactériologie, Université du Québec, Laval-des-Rapides, C.P. 100, H7N 4Z3 Laval, Québec, Canada;(2) Centre de Recherche en Immunologie, Institut Armand-Frappier, Université du Québec, Laval-des-Rapides, C.P. 100, H7N 4Z3 Laval, Québec, Canada;(3) Departement de Pathologie et Microbiologie, Faculté de Médecine Vétérinaire, Université de Montréal, C.P. 5000, J2S 7C6 St. Hyacinthe, Québec, Canada |
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| Abstract: | The biological properties ofTreponema hyodysenteriae hemolysin (TH), which in some aspects resembles streptolysin S, were studied. Aside from different erythrocyte species, TH had no lytic activity on prokaryotic (protoplasts and spheroplasts) and eukaryotic (Chinese hamster ovary and spleen) cells. However, TH decreased the response of spleen cells to concanavalin A and lipopolysaccharide. In vivo, TH was found to induce fluid accumulation in ligated rat ileal loops as well as histological modifications similar to those observed in the swine dysentery. These results further differentiate TH from streptolysin S, and suggest that it is a new oxygen-resistant hemolysin produced by a Gram-negative bacterium. |
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