SECISDesign: a server to design SECIS-elements within the coding sequence |
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| Authors: | Busch Anke Will Sebastian Backofen Rolf |
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| Institution: | Friedrich-Schiller-University Jena, Institute of Computer Science, Ernst-Abbe-Platz 2, 07743 Jena, Germany. |
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| Abstract: | SUMMARY: SECISDesign is a server for the design of SECIS-elements and arbitrary RNA-elements within the coding sequence of an mRNA. The element has to satisfy both structure and sequence constraints. At the same time, a certain amino acid similarity to the original protein has to be kept. The designed sequence can be used for recombinant expression of selenoproteins in Escherichia coli. AVAILABILITY: The server is available at http://www.bio.inf.uni-jena.de/Software/SECISDesign/index.html. |
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