ABO blood groups,leprosy, and serum proteins |
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Authors: | F Vogel J Krüger Y K Song G Flatz |
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Institution: | (1) Institute of Anthropology and Human Genetics of the University Heidelberg, Germany;(2) McKean Hospital, Chiang Mai, Thailand;(3) Human Genetics Laboratory, Department of Pathology, Faculty of Medicine, Chiang Mai University, Thailand |
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Abstract: | Summary In 683 leprosy patients from Chiang Mai, Thailand, the associations between ABO blood groups, type and clinical features of leprosy, and electrophoretically identifiable serumprotein fractions (albumins: 1-, 2-, - and -globulins) were examined. Besides, the blood group frequencies in 388 leprosy patients were compared with suitable controls. Blood groups A and AB turned out to be somewhat more frequent in patients than in controls. Combined analysis with 31 series from literature reports gave X=1.0776; 2=1)=12.232. In comparisons within our group of patients which contained almost exclusively lepromatous and dimorphous patients a certain tendency towards more severe involvement of blood group A was observed within the lepromatous group and a higher frequency of eye involvement in group A was (weakly) significant (2=1)=6.188).As to serum proteins 1- and 2-globulins were decreased (weakly) significantly in blood group A patients who were at least 40 years old. Furthermore, a number of relationships of serum protein fractions with age, sex, and state of the infection, most of which are known from the literature, could be confirmed. |
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