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Influence of sodium succinate and malonate on the histamine release in the anaphylactic reaction in vitro
Authors:MOUSSATCHE H  PROUVOST-DANON A
Affiliation:1. Developmental Neuroscience Department, Great Ormond Street, Institute of Child Health, UCL, London, United Kingdom;2. Department of Microbial Biotechnology, University of Tehran, Tehran, Iran;3. Max Perutz Labs, University of Vienna, Vienna Biocenter (VBC), Dr. Bohr-Gasse 9, Vienna, Austria;4. Department of Biology, Rasht Branch, Islamic Azad University, Rasht, Iran;5. Department of Biological Science and Technology, University of Isfahan, Isfahan, Iran;6. Department of Biology, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran;7. Guilan University of Medical Sciences, Rasht, Iran;1. Department of Pharmacy, Beijing Hospital, National Centre of Gerontology, Beijing, P.R. China;2. Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, P.R. China;1. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Bicêtre, Service de Médecine Interne et Immunologie Clinique, 94275 Le Kremlin-Bicêtre, France;2. Université Paris-Sud, 94275 Le Kremlin-Bicêtre, France;3. Gustave Roussy, Département de Médecine Oncologique, 94805 Villejuif, France;4. Institut Pasteur, Unité d’Epidémiologie des Maladies Emergentes, 75015 Paris, France;5. AP-HP, Hôpital Bicêtre, Service de Pneumologie, 94275 Le Kremlin-Bicêtre, France;6. AP-HP, Hôpital Bicêtre, Département de Microbiologie, 94275 Le Kremlin-Bicêtre, France;7. Service de Santé des Armées, Hôpital Bégin, Département de Biochimie, 94160 Saint-Mandé, France;8. Université de Nantes, Inserm UMR 1087/CNRS UMR 6291, 44007 Nantes, France;9. L’institut du thorax, Service de Pneumologie, Hôpital G. et R. Laënnec, CHU de Nantes, 44093 Nantes cedex 1, France
Abstract:Succinate increases and malonate decreases the amount of histamine liberated by sensitized guinea-pig lung slices submitted to the anaphylactic reaction. The results indicate a linkage between cellular metabolism and the mechanism of histamine release by antigen-antibody reaction.
Keywords:
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