In vivo rat metabolism and pharmacokinetic studies of ginsenoside Rg3 |
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Authors: | Qian Tianxiu Cai Zongwei Wong Ricky N S Mak Nai Ki Jiang Zhi-Hong |
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Institution: | Department of Chemistry, Hong Kong Baptist University, 224 Waterloo Road, Kowloon, Hong Kong, SAR, China. |
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Abstract: | Metabolism of an anti-tumor active component of Panax ginseng, ginsenoside (20R)-Rg(3), was studied for better understanding its pharmacokinetics in rat. LC-MS was used to determine Rg(3) and its metabolites in rat plasma, urine and feces samples. An average half-life of 18.5 min was obtained after the ginsenoside was intravenously dosed at 5 mg/kg. However, Rg(3) was not detected in rat plasma collected after oral administration at 100 mg/kg. Only 0.97-1.15% Rg(3) of the dosed amount was determined in feces. Hydrolysis and oxygenated metabolites were detected and identified in feces collected after oral administration by using LC-MS and MS-MS. |
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