Phosphorylation of elongation factor 1 in polyribosome fraction of rabbit reticulocytes |
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Authors: | E K Davydova A S Sitikov L P Ovchinnikov |
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Institution: | Institute of Protein Research, Academy of Sciences of the USSR, 142292 Pushchino, Moscow Region, USSR |
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Abstract: | A single protein, Mr approximately 50000, is shown to be phosphorylated during incubation of a mono- and polyribosome fraction of rabbit reticulocytes with gamma-32P]ATP at a low ionic strength. This protein has been identified as the elongation factor 1 alpha (EF-1 alpha). The phosphorylated EF-1 alpha, in contrast to the unmodified factor, is not detected in complexes with mono- and polyribosomes. It is suggested that the phosphorylation of EF-1 alpha can result in its decompartmentation from polyribosomes and thus affect the rate of protein synthesis. |
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Keywords: | Elongation factor 1 Protein phosphorylation Polyribosome Translation regulation Compartmentation-decompartmentation |
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