NAADP: a new second messenger comes of age |
| |
Authors: | Santella Luigia |
| |
Affiliation: | Laboratory of Cell Signaling, Stazione Zoologica A. Dohrn, Villa Comunale I-80121, Napoli, Italy. |
| |
Abstract: | Nicotinic acid adenine dinucleotide phosphate (NAADP) is one of the most potent stimulators of intracellular Ca(2+) mobilization in a variety of cell types. Its role in physiological processes is increasingly demonstrated by NAADP increases following cellular stimulation. As a second messenger NAADP shows unique features such as the ability to mobilize Ca(2+) from stores that are physically distinct from those connected to the Ca(2+) channels located in the endoplasmic reticulum, namely, the inositol-1,4,5-trisphosphate and the cyclic-ADP-ribose/ ryanodine receptors. Furthermore, the NAADP-induced self-inactivation mechanism is suggestive of an irreversible binding of NAADP to its putative receptor. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|