Glycolipoprotein extract (G-90) from earthworm Eisenia foetida exerts some antioxidative activity |
| |
Authors: | Grdisa M Popovic M Hrzenjak T |
| |
Institution: | Division of Molecular Medicine, Rudjer Boskovic Institute, Bijenicka 54, 10-000, Zagreb, Croatia. grdisa@rudjer.irb.hr |
| |
Abstract: | Antioxidants protect DNA, proteins and lipids in the body from damage. These types of damages are a major contributor to aging and to degenerative diseases such as cancer, cardiovascular disease, immune-system decline, brain dysfunction and cataracts. The effect of glycolipoprotein extract of Eisenia foetida (G-90) as an antioxidant was investigated in cultured human fibroblasts and epithelial cells. After treatment of the cells with H2O2 for 4 h, G-90 completely allows the cells to recover and stimulated their growth. When the cells were incubated with G-90 48 h before the treatment with H2O2, the oxidative damage of the cells did not occur. Thus, G-90 had an apparent protective effect against the toxicity of H2O2 and stimulated the growth of the cells. Ascorbic acid, a known antioxidant, did not allow the growth of the cells to recover after damage nor did it protect them, unless it was added simultaneously with H2O2. The antioxidative activity of G-90, together with its antibacterial and mitogen activities, could be useful in the study of G-90 as a wound-healing agent. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|