Positive correlation between virulence of Pseudomonas aeruginosa mutants in mice and insects |
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| Authors: | Jander G Rahme L G Ausubel F M |
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| Institution: | Department of Genetics, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. |
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| Abstract: | Strain PA14, a human clinical isolate of Pseudomonas aeruginosa, is pathogenic in mice and insects (Galleria mellonella). Analysis of 32 different PA14 mutants in these two hosts showed a novel positive correlation in the virulence patterns. Thus, G. mellonella is a good model system for identifying mammalian virulence factors of P. aeruginosa. |
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