Studies on induced aberrations in diplochromosomes of Chinese hamster cells

We have classified the commoner aberrations that can be scored in a diplochromosome. This chromosome configuration can be useful for a study of the mechanisms that underlie chromosome aberrations. Three experiments were done in which endoreduplicated Chinese hamster cell (strain CHEF-125) were irradiated at various stages in their cell cycle. The results showed good consistency in the three experiments and confirmed that the spatial arrangement of the chromosomes influences both the type and the frequency of the aberrations produced.