Opsonizing properties of natural antibodies of rainbow trout, Oncorhynchus mykiss (Walbaum) |
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| Authors: | C. Michel,R. Gonzalez,&dagger S. Avrameas,&dagger |
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| Affiliation: | Laboratoire d'Ichtyopathologie, Institut National de la Recherche Agronomique, Centre de Recherches de Jouy-en-Josas, 78350 Jouy-en-Josas;Unitée ďImmunocytochimie, Institut Pasteur, 75015 Paris, France |
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| Abstract: | In order to confirm previous observations in which a protective effect of rainbow trout natural antibodies against furunculosis was suspected, phagocytosis studies wereconducted in vitro , using combinations of rainbow trout sera with high or low levels of natural antibodies and active or inactivated complement as opsonizing factors. Opsonization was observed in all the cases where complement was present, and to a lesser degree with sera containing only natural antibodies. The results confirm the prime importance of the complement system and provide additional evidence for a possible role of natural antibodies in antimicrobial defences. |
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| Keywords: | Oncorhynchus mykiss antibodies opsonizing factors |
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