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The role of glutathione in renal cortical tissue. effects of diamide on Na+ and GSSG levels,amino acid transport and Na+-K+-ATPase activity |
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| Authors: | Pillion Dennis J. Moree Lamar Rocha Hector Pashley David H. Mendicino Joseph Leibach Frederick H. |
| Affiliation: | (1) Department of Cell and Molecular Biology, Medical College of Georgia Augusta, 30902 Georgia;(2) Department of Physiology, Medical College of Georgia Augusta, 30902 Georgia;(3) Department of Biochemistry, University of Georgia Athens, 30602 Georgia, USA;(4) Division of Biology and Medicine, Brown University, 02912 Providence, Rhode Island |
| Abstract: | Summary The effects of diamide were studied in rat kidney cortical tissue. It was found that diamide increased oxidized glutathione levels and inhibited Na+-K+-ATPase activity. Consistent with this finding was the observation that diamide compromised the sodium gradients maintained in renal cortical slices. Amino acid transport studies with ouabain or a sodium-free buffer indicated that diamide interferes with both Na+-dependent and Na+-independent transport systems. These results indicate that diamide has a number of different effects on renal cortical tissue and emphasize the important role of glutathione in maintaining control of a number of key metabolic pathways. |
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