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Relaxation of Mytilus smooth muscle in low sodium.
Authors:Y Muneoka  B M Twarog  T Mikawa
Affiliation:1. Department of Physiology, Hiroshima University School of Dentistry, Hiroshima 734, Japan;2. Department of Anatomical Sciences, School of Basic Health Sciences, Health Sciences Center, SUNY at Stony Brook, Stony Brook, New York 11794, U.S.A.;1. Department of Neurology, Zibo Central Hospital, Zibo, 255000, China;2. Department of Emergency Medicine, Zibo Central Hospital, Zibo, 255000, China;3. Department of Medical Laboratory, Zibo Central Hospital, Zibo, 255000, China;1. Department of Physiology, School of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong, 518055, China;2. International Cancer Center, Shenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong, 518055, China;3. School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong, 518055, China;4. Songgang People''s Hospital, Shenzhen, Guangdong, 518105, China;1. CERVO Brain Research Centre, Quebec City, Quebec, Canada;2. Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia;3. Department of Medicine, Faculty of Medicine, Université Laval, Quebec City, Quebec, Canada
Abstract:1. Reduced external Na+ relaxed catch contraction in the anterior byssus retractor muscle (ABRM) of Mytilus. This relaxation was inhibited by mersalyl. La3+ also inhibited when applied under conditions in which it penetrated beyond superficial sites on the membrane.2. Theophylline enhanced the relaxation and caffeine retarded it. After pretreating the muscle with Na+-deficient physiological saline (0 Na+ ASW), caffeine contracture increased.3. Efflux of 45Ca2+ decreased in 0 Na+ ASW; the evidence suggests a Na+−Ca2+ exchange.4. The mechanism of the relaxation is discussed with reference to release of serotonin at nerve endings and to the level of intracellular Ca2+ and cyclic AMP.
Keywords:
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