Structural analysis of a mature hst-1 protein with transforming growth factor activity. |
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| Authors: | K Miyagawa S Kimura T Yoshida H Sakamoto F Takaku T Sugimura M Terada |
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| Institution: | Genetics Division, National Cancer Center Research Institute, Tokyo, Japan. |
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| Abstract: | A recombinant hst-1 protein produced in silkworm cells by a recombinant baculovirus, previously shown to be a potent mitogen for NIH3T3 cells and human endothelial cells, also stimulated anchorage-independent growth of NRK-49F cells. Amino acid sequence analysis revealed that the amino-terminal sequence with 58 amino acids was cleaved off in silkworm cells. These results indicated that the mature hst-1 protein consisting of 148 amino acids had transforming growth factor activity. |
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