Furans with basic side chains: synthesis and biological evaluation of a novel series of antagonists with selectivity for the estrogen receptor alpha. |
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| Authors: | D S Mortensen A L Rodriguez J Sun B S Katzenellenbogen J A Katzenellenbogen |
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| Affiliation: | Department of Chemistry, University of Illinois, Urbana, 61801, USA. |
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| Abstract: | 3-alkyl-2,4,5-triarylfurans with basic side-chain substituents were prepared as ligands for the estrogen receptor. Those analogues having the basic side chain on the C(4) phenol were high-affinity, ERalpha-selective antagonists. |
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