| 基于纳米颗粒的基因突变检测方法研究进展 |
| |
| 引用本文： | 王蕾蕾,董莲华,杨靖亚,王霞. 基于纳米颗粒的基因突变检测方法研究进展[J]. 生物技术通报, 2021, 0(3): 241-251 |
| |
| 作者姓名： | 王蕾蕾 董莲华 杨靖亚 王霞 |
| |
| 作者单位： | 上海海洋大学食品学院;中国计量科学研究院前沿计量科学中心 |
| |
| 基金项目： | 国家质量基础共性关键技术重点研发专项(2017YFF0204605)。 |
| |
| 摘 要： | 基因突变是指在分子结构上发生碱基对的组成或排列顺序的改变.它与人类疾病的发生息息相关,一直以来备受关注,开发准确可靠的检测方法,进一步探索核酸功能调控以及相关疾病的早期发现和治疗是研究人员不断努力的方向.近年来,纳米颗粒因其优异的光学、电学和生物相容性,在生物医学领域得到广泛应用.首次系统地论述基于纳米颗粒在基因突变检...
|
| 关 键 词： | 纳米颗粒 荧光法 单颗粒计数法 基因突变 |
Research Progress of Gene Mutation Detection Methods Based on Nanoparticles |
| |
| WANG Lei-lei,DONG Lian-hua,YANG Jing-ya,WANG Xia. Research Progress of Gene Mutation Detection Methods Based on Nanoparticles[J]. Biotechnology Bulletin, 2021, 0(3): 241-251 |
| |
| Authors: | WANG Lei-lei DONG Lian-hua YANG Jing-ya WANG Xia |
| |
| Affiliation: | (College of Food Sciences&Technology,Shanghai Ocean University,Shanghai 201306;Frontier Metrology Science Center,National Institute of Metrology,Beijing 100029) |
| |
| Abstract: | Gene mutation refers to a change in the composition or sequence of base pairs in the molecular structure.It is closely related to the occurrence of human diseases and has always attracted attention.The development of accurate and reliable detection methods,the further exploration of nucleic acid function regulation and the early detection and treatment of related diseases are the directions of researchers’continuous efforts.In recent years,nanoparticles have been widely used in the field of biomedicine due to their excellent optical-,electricaland bio-compatibility.It is the first work to systematically discuss the latest research progress in gene mutation detection based on the nanoparticle,to explain the main issues and challenges in this field,and to look forward to the future development trend,aiming to provide new options for gene mutation detection ideas. |
| |
| Keywords: | nanoparticles fluorescence method single particle counting method gene mutation |
| 本文献已被 维普 等数据库收录！ |
|
