Plasma F2-isoprostane level and cognitive function over eight years in non-demented older adults: Findings from the Health ABC Study |
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| Authors: | AJ Fiocco AM Kanaya KM Lindquist TB Harris S Satterfield EM Simonsick L Kuller C Rosano K Yaffe |
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| Institution: | 1. GGZ inGeest, VU University Medical Center, Amsterdam, The Netherlands;2. Department of Psychiatry, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands;3. Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands;1. Department of Clinical Biochemistry, Nicolaus Copernicus University in Torun, The Ludwik Rydygier Collegium Medicum in Bydgoszcz, Poland;2. Department of Paediatrics, Haematology and Oncology, Nicolaus Copernicus University in Torun, The Ludwik Rydygier Collegium Medicum in Bydgoszcz, Poland;3. District Health Center in Kartuzy, Poland |
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| Abstract: | F2-isoprostanes (F2-IsoP) are reportedly increased in dementia patients, and are considered a reliable biomarker of oxidation. However, few studies have examined the predictive value of peripheral F2-IsoP levels in non-demented older adults. This study assesses the association between plasma F2-IsoP and change in cognitive function in non-demented elderly over eight years. Plasma F2-IsoP was measured by gas chromatography-mass spectrometry in a biracial cohort of 726 elderly men and women. Digit Symbol Substitution test and the Modified Mini-Mental State Exam were administered over time. No association was found between F2-IsoP tertile and baseline or change (slope) in cognitive function over eight years. Plasma F2-IsoP is not a valuable biomarker in predicting cognitive change over years in non-demented older adults. |
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