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| 嘧啶核苷磷酸化酶与抗癌药物治疗效果的评价 | |
| 引用本文： | 姜立春,韩文君,彭正松,阮期平. 嘧啶核苷磷酸化酶与抗癌药物治疗效果的评价[J]. 生物技术通讯, 2006, 17(6): 970-972 |
| 作者姓名： | 姜立春 韩文君 彭正松 阮期平 |
| 作者单位： | 1. 绵阳师范学院,分子生物学与生物制药重点实验室,四川,绵阳,621000;西华师范大学,生命科学学院,四川,南充,637002 2. 绵阳师范学院,分子生物学与生物制药重点实验室,四川,绵阳,621000 3. 西华师范大学,生命科学学院,四川,南充,637002 |
| 摘 要： | 嘧啶核苷磷酸化酶(PyNPase)是嘧啶核苷补救代谢途径中的关键酶,广泛分布于微生物及动物组织细胞中。近几年来,很多学者对PyNPase在抗癌药物合成和癌症治疗方面的作用及其临床应用进行了广泛的研究。本文综述了PyNPase与肿瘤患者临床病理特征、抗癌药物评价等之间的关系。 |
| 关 键 词： | 嘧啶核苷磷酸化酶 癌症研究 临床应用 |
| 文章编号： | 1009-0002(2006)06-0970-03 |
| 收稿时间： | 2006-02-14 |
| 修稿时间： | 2006-02-14 |
Pyrimidine Nucleoside Phosphorylase and the Evaluation of Anticancer Drugs |
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| JIANG Li-chun,HAN Wen-jun,PENG Zheng-song,RUAN Qi-ping. Pyrimidine Nucleoside Phosphorylase and the Evaluation of Anticancer Drugs[J]. Letters in Biotechnology, 2006, 17(6): 970-972 | |
| Authors: | JIANG Li-chun HAN Wen-jun PENG Zheng-song RUAN Qi-ping |
| Affiliation: | 1. Key laboratory for Morlecular Biology and Biopharmaceuticals, Mianyang Normal University, Mianyang, 621000; 2. College of Life Science, China West Normal University, Nanchong 637002; China |
| Abstract: | Pyrimidine nucleoside phosphorylase(PyNPase) is a key enzyme in the pyrimidine salvage pathway, broadly distributed in various microorganism and mammalian cells. In recently several years, PyNPase has been extensively attention to reports in the synthesis of anticancer drugs and the chemotherapy of various tumors. This paper summarized the relation of the PyNPase and clinic pathological characteristic and the evaluation of anticancer drugs. |
| Keywords: | pyrimidine nucleoside phosphorylase cancer research clinical application |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |