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Induction of broad and potent anti-human immunodeficiency virus immune responses in rhesus macaques by priming with a DNA vaccine and boosting with protein-adsorbed polylactide coglycolide microparticles
Authors:Otten Gillis  Schaefer Mary  Greer Catherine  Calderon-Cacia Maria  Coit Doris  Kazzaz Jina  Medina-Selby Angelica  Selby Mark  Singh Manmohan  Ugozzoli Mildred  zur Megede Jan  Barnett Susan W  O'Hagan Derek  Donnelly John  Ulmer Jeffrey
Institution:Vaccines Research, Chiron Corporation, Emeryville, California 94608, USA. Gillis_Otten@chiron.com
Abstract:Several vaccine technologies were evaluated for their abilities to induce anti-human immunodeficiency virus Gag immune responses in rhesus macaques. While no vaccine alone was able to induce broad and strong immune responses, these were achieved by priming with Gag DNA and boosting with Gag protein adsorbed to polylactide coglycolide microparticles. This regimen elicited strong antibodies, helper T cells, and cytotoxic T lymphocytes and thus holds promise as an effective vaccination scheme.
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