Induction of broad and potent anti-human immunodeficiency virus immune responses in rhesus macaques by priming with a DNA vaccine and boosting with protein-adsorbed polylactide coglycolide microparticles |
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Authors: | Otten Gillis Schaefer Mary Greer Catherine Calderon-Cacia Maria Coit Doris Kazzaz Jina Medina-Selby Angelica Selby Mark Singh Manmohan Ugozzoli Mildred zur Megede Jan Barnett Susan W O'Hagan Derek Donnelly John Ulmer Jeffrey |
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Institution: | Vaccines Research, Chiron Corporation, Emeryville, California 94608, USA. Gillis_Otten@chiron.com |
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Abstract: | Several vaccine technologies were evaluated for their abilities to induce anti-human immunodeficiency virus Gag immune responses in rhesus macaques. While no vaccine alone was able to induce broad and strong immune responses, these were achieved by priming with Gag DNA and boosting with Gag protein adsorbed to polylactide coglycolide microparticles. This regimen elicited strong antibodies, helper T cells, and cytotoxic T lymphocytes and thus holds promise as an effective vaccination scheme. |
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