Persistence of exogenous, inserted ganglioside GM1 on the cell surface of cultured cells |
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| Authors: | E O'Keefe P Cuatrecasas |
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| Affiliation: | 1. The Johns Hopkins University School of Medicine Baltimore, Maryland 21205, USA;1. The Wellcome Research Laboratories Research Triangle Park, North Carolina 27709, USA |
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| Abstract: | Ganglioside GM1, which can insert spontaneously into the membrane of intact cells, has been measured after insertion into transformed fibroblasts by cholera toxin (choleragen) binding, for which ganglioside GM1 is the natural receptor. Choleragen binding is not altered in starved, quiescent cells over a four-day period. Dividing cells show decreased binding in proportion to cell division. Thus, neither dividing nor quiescent cells appear to metabolize or otherwise degrade this membrane component. |
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| Keywords: | To whom reprint requests should be addressed. |
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