Effects of inhibitors of arachidonic acid metabolism on intercellular adhesion of SV40-3T3 cells |
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| Authors: | P M Evans D F Lanham |
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| Institution: | 1. Department of Chemical and Biological Engineering, University of Alabama, Tuscaloosa, United States;2. Department of Chemical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran;3. Department of Chemical and Biomolecular Engineering, University of Nebraska−Lincoln, Lincoln, NE, United States;1. National Human Genome Research Institute (NHGRI), NIH, Bethesda, MD 20892, USA;2. Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA;3. National Institute of Neurological Disorders and Stroke (NINDS), NIH, Bethesda, MD 20892, USA;4. National Cancer Institute (NCI), NIH, Bethesda, MD 20892, USA;5. National Institute on Aging (NIA), NIH, Baltimore, MD 21224, USA;1. Department of Biology, San Diego State University, San Diego, CA, USA;2. Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada;3. Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada;4. Ontario Institute for Cancer Research, Toronto, ON, Canada;5. Department of Physics, University of California, San Diego, La Jolla, CA, USA;6. Division of Biological Sciences, University of California, San Diego, La Jolla, CA, USA;1. Universidad de San Andrés, Vito Dumas 284, San Fernando, Buenos Aires, Argentina;2. Financial Research Unit, Financial Policy Division, Central Bank of Chile, Chile;3. Universidad del Desarrollo Av Plaza 680, Las Condes, Santiago, Chile;1. Princess of Wales Hospital, Coity Road, Bridgend CF31 1RQ, UK;2. Neath Port Talbot Hospital, Port Talbot SA12 8YL, UK |
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| Abstract: | Mepacrine, an inhibitor of arachidonic acid mobilisation, and NDGA, a lipoxygenase inhibitor, were found to impair the aggregation of SV40-3T3 cells but the effects could not be unequivocally dissociated from non-specific actions of the drugs. No effect on aggregation was observed even after prolonged exposure of the cells to the cyclooxygenase inhibitors aspirin and indomethacin. These results argue against a possible regulatory role for endogenous AA metabolites in intercellular adhesion of SV40-3T3 cells. |
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