缺氧条件下FMMU白化豚鼠和杂色豚鼠心肌线粒体形态变化比较研究

目的　比较研究在缺氧条件下FMMU白化豚鼠和杂色豚鼠心肌线粒体的形态变化。方法　将FMMU白化豚鼠和杂色豚鼠置于常压缺氧舱内分别缺氧 7d、14d、2 1d ,复制常压缺氧模型 ,分别取FMMU白化豚鼠和杂色豚鼠心肌 ,电镜下观察心肌线粒体形态的变化。结果　在同一缺氧时间 ,二者的超微结构变化程度不同 ;在不同缺氧时间 ,同种豚鼠的变化程度也不同。结论　在缺氧条件下 ,FMMU白化豚鼠心肌线粒体的变化程度较杂色豚鼠轻 ,提示可能白化豚鼠对缺氧的耐受性优于杂色豚鼠

Comparative Study on Structure of Myocardial Mitochondria between FMMU Albino Guinea-Pigs and Pigment Ones Submitted to Chronic Hypoxia

Objective Structure of myocardial mitochondria between FMMU albino guinea pigs and pigment ones was compared after exposed to hypoxia. Methods FMMU albino guinea pigs and pigment ones were placed in hypoxic chamber at normal pressure for 7 d,14 d,21 d respectively to make hypoxic model. Cardiac muscle was taken out and the structure of myocardial mitochondrial was observed under electron microscope. Results In the same hypoxia the myocardial ultrastructure of FMMU albino guinea pigs and pigment ones changed in varying degrees. In different hypoxic stage the ultrastructure of the same guinea pigs changed in varying degrees, too. Conclusion Change degrees of myocardial ultrastructure of FMMU albino guinea pigs were lighter than that of pigment ones under hypoxic circumstances. It hinted that the anoxia tolerance of FMMU albino guinea pigs was higher than that of pigment ones.