Biogenesis of iron-sulfur proteins in eukaryotes: components, mechanism and pathology |
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Authors: | Gerber Jana Lill Roland |
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Affiliation: | Institut für Zytobiologie und Zytopathologie der Philipps-Universit?t Marburg, Robert-Koch-Strasse 5, 35033 Marburg, Germany. |
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Abstract: | Iron-sulfur (Fe-S) clusters are ubiquitous co-factors of proteins that play an important role in metabolism, electron-transfer and regulation of gene expression. In eukaryotes mitochondria are the primary site of Fe-S cluster biogenesis. The organelles contain some ten proteins of the so-called iron-sulfur cluster (ISC) assembly machinery that is well-conserved in bacteria and eukaryotes. The ISC assembly machinery is responsible for biogenesis of Fe-S proteins within mitochondria. In addition, this machinery is involved in the maturation of extra-mitochondrial Fe-S proteins by cooperating with mitochondrial proteins with an exclusive function in this process. This review summarizes recent developments in our understanding of the biogenesis of cellular Fe-S proteins in eukaryotes. Particular emphasis is given to disorders in Fe-S protein biogenesis causing human disease. |
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