Measurement of aromatisation by a urine technique suitable for the evaluation of aromatase inhibitors in vivo. |
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| Authors: | S Jacobs P E L?nning B Haynes L Griggs M Dowsett |
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| Institution: | Department of Academic Biochemistry, Royal Marsden Hospital, London, England. |
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| Abstract: | By modification of a recently developed method for separation of radio-labelled urinary oestrogens we were able to separate oestrogen metabolites and measure their isotope ratios in urine following injections of 3H]delta 4-androstenedione and 14C]oestrone. This method provides a useful tool for studying in vivo aromatisation of delta 4-androstenedione into oestrone in breast cancer patients before and during treatment with aromatase inhibitors. |
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