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| 人参皂甙Rg1对脑缺血再灌注大鼠脑组织Bax和Bcl-2蛋白表达的影响 | |
| 引用本文： | 包翠芬,刘霞,魏嘉,梁佳,秦书俭.人参皂甙Rg1对脑缺血再灌注大鼠脑组织Bax和Bcl-2蛋白表达的影响[J].中国组织化学与细胞化学杂志,2009,18(2):217-221. |
| 作者姓名： | 包翠芬 刘霞 魏嘉 梁佳 秦书俭 |
| 作者单位： | 1. 辽宁中医药大学组胚教研室,沈阳,110032;辽宁医学院科学实验中心 2. 辽宁医学院组胚教研室 3. 辽宁医学院科学实验中心 4. 辽宁中医药大学组胚教研室,沈阳,110032;辽宁医学院解剖学教研室,锦州,121000 |
| 摘 要： | 目的探讨人参皂甙Rg1对脑缺血再灌注大鼠脑组织Bcl-2和Bax表达的影响及其意义。方法分别给大鼠腹腔注射人参皂甙Rg1 10、20、40 mg/kg,采用大脑中动脉闭塞方法建立脑缺血再灌注模型,观察大鼠脑缺血再灌注后不同时间段（2 h、24 h）神经功能缺损评分;应用免疫组化法检测脑组织缺血再灌注24h后Bcl-2、Bax的表达。结果人参皂甙Rg1组大鼠脑缺血后各时间点神经功能缺损评分显著低于单纯缺血再灌注组（P〈0.05）;与单纯缺血再灌注组相比,人参皂甙Rg1各组Bcl-2表达显著增高,Bax表达显著降低,Bcl-2/Bax比值显著上调（P〈0.05）。结论人参皂甙Rg1防治大鼠脑缺血再灌注损伤的机制可能与促进脑组织Bcl-2表达、抑制Bax表达有关,且以高剂量效果较好。 |
| 关 键 词： | 人参皂甙Rg1 脑缺血再灌注 Bcl-2 Bax |
EFFECTS OF GINSENOSIDE RG1 ON EXPRESSIONS OF BCL-2 and BAX IN RAT BRAIN TISSUE AFTER CEREBRAL ISCHEMIA-REPERFUSION IN RATS |
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| Bao Cuifen,Liu Xia,Wei Jia,Liang Jia,Qin Shujian.EFFECTS OF GINSENOSIDE RG1 ON EXPRESSIONS OF BCL-2 and BAX IN RAT BRAIN TISSUE AFTER CEREBRAL ISCHEMIA-REPERFUSION IN RATS[J].Chinese Journal of Histochemistry and Cytochemistry,2009,18(2):217-221. | |
| Authors: | Bao Cuifen Liu Xia Wei Jia Liang Jia Qin Shujian |
| Institution: | 1Department of Histology and Embryology;Liaoning University of Traditional Chinese Medicine;Shenyang 1100321;2Centre of Scientific Experiment;3Department of Histology and Embryology;4Department of Anatomy;Liaoning Medical College;Jinzhou 121001;China |
| Abstract: | Objective To study the effects of Ginsenoside Rg1 on the expressions of Bcl-2 and Bax in brain tissue after focal cerebral ischemia-reperfusion in adult rats.Methods Ginsenoside Rg1 was given intraperitoneally to the rats once a day at the dose of 10,20 and 40 mg/kg,respectively.Then the models of cerebral ischemia-reperfusion were made by middle cerebral artery occlusion in rats.At 2 and 22h after focal cerebral ischemia-reperfusion,the neurological deficit score was evaluated and immunohistochemistry was ... |
| Keywords: | Bcl-2 Bax |
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