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Influence of lysophosphatidic acid on estradiol production and follicle stimulating hormone action in bovine granulosa cells |
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| Authors: | Dorota Boruszewska Emilia Sinderewicz Ilona Kowalczyk-Zieba Dariusz Jan Skarzynski Izabela Woclawek-Potocka |
| Institution: | 1. Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA;2. Department of Biochemistry and Molecular Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;3. Center for Cancer Epigenetics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;4. Advanced Photon Source, Argonne National Laboratory, Argonne, IL 60439, USA;5. Nutraceuticals and Functional Food Research and Development Center, Faculty of Agro-Industry, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand |
| Abstract: | The objective of the study was to examine the effect of lysophosphatidic acid (LPA) on 17β-estradiol (E2) synthesis and follicle stimulating hormone (FSH) action in bovine granulosa cells. We found that granulosa cells in the bovine antral follicle, in addition to the uterus and the CL, are also the site of LPA synthesis and the target for LPA action in the bovine reproductive tract. Our findings suggest that LPA stimulates E2 synthesis, probably via increased expression of FSHR and 17β-HSD genes. |
| Keywords: | Lysophosphatidic acid Granulosa cells Cow Estradiol Follicle stimulating hormone LPAR Autotaxin Phospholipase A2 |
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