Roles of MicroRNAs in the Caenorhabditis elegans Nervous System |
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| Authors: | Lingfeng Meng Liang Chen Zhaoyong Li Zheng-Xing Wu Ge Shan |
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| Affiliation: | 1. School of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou 450002, China;2. Environment Functional Materials Division, Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China;3. Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA |
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| Abstract: | The first microRNA was discovered in Caenorhabditis elegans in 1993, and since then, thousands of microRNAs have been identified from almost all eukaryotic organisms examined. MicroRNAs function in many biological events such as cell fate determination, metabolism, apoptosis, and carcinogenesis. So far, more than 250 microRNAs have been identified in C. elegans; however, functions for most of these microRNAs are still unknown. A small number of C. elegans microRNAs are associated with known physiological roles such as developmental timing, cell differentiation, stress response, and longevity. In this review, we summarize known roles of microRNAs in neuronal differentiation and function of C. elegans, and discuss interesting perspectives for future studies. |
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| Keywords: | Nervous system MicroRNA Function Differentiation |
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