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Inhibition of endometrial fundocervical wave by phloroglucinol and the outcome of in vitro fertilization
Authors:Aizhuang Xu  Yanping Li  Lin Zhu  Tian Tian  Jie Hao  Jing Zhao  Qiong Zhang
Affiliation:1. Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341, South Korea;2. Department of Biomedical Science and Research Institute for Bioscience and Biotechnology, Hallym University, Chuncheon 24252, South Korea;3. Department of Emergency Medicine and Institute of Medical Sciences, School of Medicine, Kangwon National University, Chuncheon 24341, South Korea;4. Department of Pediatrics, Chuncheon Sacred Heart Hospital, College of Medicine, Hallym University, Chunchen 24253, South Korea;5. Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chuncheon 24341, South Korea;6. Department of Pharmacy, College of Pharmacy, Dankook University, Cheonan 31116, South Korea
Abstract:One hundred thirty-five infertile patients were enrolled to investigate the efficacy of phloroglucinol-induced inhibition of the endometrial fundocervical wave and its effect on in vitro fertilization (IVF). We found that phloroglucinol significantly inhibited (P < 0.05) peristaltic fundocervical wave, suggesting a feasible way of application of phloroglucinol to suppress endometrial waves during IVF.
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