Rosmarinic acid production in Coleus cell cultures |
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Authors: | A Razzaque B E Ellis |
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Institution: | (1) Guelph-Waterloo Centre for Graduate Work in Chemistry, University of Guelph, N1G 2W1 Guelph, Ont., Canada |
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Abstract: | Cell suspension cultures of Coleus blumei Benth. have been found to accumulate 8–11% of their dry weight as rosmarinic acid ( -O-caffeoyl-3,4-dihydroxyphenyl-lactic acid). Actively-growing tissue converts >20% of exogenously supplied phenylalanine and tyrosine to the caffeoyl ester and this high rate of synthesis coincides with an increase in phenylalanine ammonia-lyase specific activity. Administration to the cultures of known phenylpropanoid precursors of rosmarinic acid failed to enhance the latter's production and in some cases inhibited it.Abbreviations RA
rosmarinic acid ( -O-caffeoyl-3,4-dihydroxyphenyllactic acid
- DOPA
dihydroxyphenylalanine
- PAL
phenylalanine ammonialyase
- DOPL
dihydroxyphenyl-lactic acid |
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Keywords: | Cell culture Coleus Rosmarinic acid |
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