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Absence of involvement of nitric oxide in LP-BM5-induced immunodeficiency syndrome
Authors:K Akarid  B Chenais  F Chau  M Sinet  B Desforges  MA Gougerot-Pocidalo
Institution:INSERM U13, 170 Boulevard Ney, 75877 Paris Cedex 18, France;CNRS URA 1116, Bât, 432, UniversitéParis-XI, 91405 Orsay, France;INSERM U294 and Laboratoire d'Immunologie et Hématologie, CHU X. Bichat, 46 rue Henri Huchard, 75877 Paris Cedex, France
Abstract:Abstract To examine the role of nitric oxide (NO) in murine AIDS (MAIDS) pathogenesis, we determined NO production and inducible NOS (iNOS) mRNA expression in the macrophages of LP-BM5-infected mice, together with the in vivo effects of l -NAME, a competitive inhibitor of NO synthase. LP-BM5 infection induced neither spontaneous nitrite production nor iNOS mRNA expression. No differences in IFNγ + LPS-induced nitrite production or iNOS mRNA expression were observed in macrophages from non-infected or infected mice. Spleen weight, ecotropic MuLV replication, the blood lymphocyte phenotype and proliferative response of splenocytes were not modified by l -NAME. LP-BM5 infection did not increase macrophage NO production and NO production did not appear to protect against LP-BM5-induced immunodeficiency.
Keywords:LP-BM5  Murine AIDS  Nitric oxide
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