Localized reversible frameshift mutation in the flhA gene confers phase variability to flagellin gene expression in Campylobacter coli |
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Authors: | Park S F Purdy D Leach S |
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Institution: | School of Biological Sciences, University of Surrey, Guildford, GU2 5XH, United Kingdom. s.park@surrey.ac.uk |
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Abstract: | Phase variation of flagellin gene expression in Campylobacter coli UA585 was correlated with high-frequency, reversible insertion and deletion frameshift mutations in a short homopolymeric tract of thymine residues located in the N-terminal coding region of the flhA gene. Mutation-based phase variation in flhA may generate functional diversity in the host and environment. |
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