Inactivation dates of the human and guinea pig vitamin C genes |
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Authors: | Marc?Y?Lachapelle Email author" target="_blank">Guy?DrouinEmail author |
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Institution: | 1.Département de biologie et Centre de recherche avancée en génomique environnementale,Université d’Ottawa,Ottawa,Canada |
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Abstract: | The capacity to biosynthesize ascorbic acid has been lost in a number of species including primates, guinea pigs, teleost
fishes, bats, and birds. This inability results from mutations in the GLO gene coding for L-gulono-γ-lactone oxidase, the enzyme responsible for catalyzing the last step in the vitamin C biosynthetic
pathway. We analyzed available primate and rodent GLO gene sequences to determine their evolutionary history. We used a method based on sequence comparisons of lineages with and
without functional GLO genes to calculate inactivation dates of 61 and 14 MYA for the primate and guinea pig genes, respectively. These estimates
are consistent with previous phylogeny-based estimates. An analysis of transposable element distribution in the primate and
rodent GLO sequences did not reveal conclusive evidence that illegitimate recombination between repeats has contributed to the loss
of exons in the primate and guinea pig genes. |
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