生物技术在传统药材生产中的应用前景

生物技术在传统药材生产中的应用前景刘涤胡之璧（上海中医药大学中药生物工程研究室，上海２０００３２）我国的中药材是一个具有数千年历史的医药宝库，至今仍在中国和许多国家和地区广为使用。传统药材中，８０％为野生资源，但由于盲目挖掘，不仅使野生资源日益减少，而且严重破坏了自然界的生态平衡；人工种植又面临品质退化，农药污染和种子带病等问题。而且，人工种植的药材，活性成分的种类和数量往往因地区及气候不同...

Perspectives of Biotechnology Application in the Production of Traditional Drugs

Biotechnology must be wide exploited in the production of traditional medicinal plants because of the progressive exhaustion of wild resources and the unstable guality of artificial cultispecies. Progresses and potentials of culture of plant cells and hairy roots,and genetic engineering applied in the production of traditinal drugs are reviewed. large scale production of some medicinal plant cells and hairy roots such as gingseng is realized via the selection of high yielding cell line,the optimization of culture condition and the design of approciate fermentor. The content of some secondary metabolites such as scopolamine is increased via genetic engineering of key enzyme. In particule,the production of some proteins derived from bacteria,animal and human via the transgenic plants as a bioreactor is researched. Finally,some results obtained in our laboratory is also concerned.