Protein turnover: a CHIP programmed for proteolysis. |
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| Authors: | T Wiederkehr B Bukau A Buchberger |
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| Affiliation: | Institute for Biochemistry and Molecular Biology, University of Freiburg, Hermann-Herder-Strasse 7, D-79104, Freiburg, Germany. |
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| Abstract: | The Hsp70 co-chaperone CHIP has recently gained attention as a regulator of protein turnover. CHIP has now been reported to be a component of the ubiquitination cascade, specifically an E3 ligase. CHIP appears to be part of a system that diverts incorrectly folded proteins from chaperones to the proteasome. |
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