Biosynthesis of bile acids in a variety of marine bacterial taxa |
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Authors: | Kim Dockyu Lee Jong Suk Kim Jiyoung Kang So-Jung Yoon Jung-Hoon Kim Won Gon Lee Choong Hwan |
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Institution: | Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-333, Korea. |
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Abstract: | Several marine bacterial strains, which were isolated from seawater off the island Dokdo, Korea, were screened to find new bioactive compounds such as antibiotics. Among them, Donghaeana dokdonensis strain DSW-6 was found to produce antibacterial agents, and the agents were then purified and analyzed by LC-MS/MS and 1D- and 2D-NMR spectrometries. The bioactive compounds were successfully identified as cholic acid and glycine-conjugated glycocholic acid, the 7alpha-dehydroxylated derivatives (deoxycholic acid and glycodeoxycholic acid) of which were also detected in relatively small amounts. Other masine isolates, taxonomically different from DSW-6, were also able to produce the compounds in a quite different production ratio from DSW-6. As far as we are aware of, these bile acids are produced by specific members of the genus Streptomyces and Myroides, and thought to be general secondary metabolites produced by a variety of bacterial taxa that are widely distributed in the sea. |
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