RTVP-1, a novel human gene with sequence similarity to genes of diverse species, is expressed in tumor cell lines of glial but not neuronal origin |
| |
Authors: | Tina Rich Pengchin Chen Felix Furman Nhung Huynh Mark A. Israel |
| |
Affiliation: | Preuss Laboratory for Molecular Neuro-oncology, Brain Tumor Research Center, Department of Neurological Surgery, School of Medicine, University of California San Francisco, San Francisco, CA 94143-0520, USA |
| |
Abstract: | A novel gene, RTVP-1, which shows significant sequence identity to the mammalian testis-specific proteins, a family of plant pathogenesis-related proteins and the vespid venom allergen, antigen-5, has been isolated from a cDNA library of the human glioblastoma brain tumor cell line, U-251 MG. The highest degree of sequence identity was with the human testis-specific protein, TPX1 (38.7% over 119 amino acids). Northern hybridization analysis revealed that in fetal tissue RTVP-1 RNA was detected only in the kidney, but its expression was ubiquitous in adult tissues including brain. Multiple mRNAs encoded by RTVP-1 were highly expressed in a panel of cell lines from nervous system tumors arising from glia, although expression was low or absent in non-glial-derived nervous system tumour cell lines. The GenBank DNA database accession number for this sequence is X91911. |
| |
Keywords: | Nervous system tumors Glioblastoma Mammalian testis-specific proteins Vespid venom antigen-5 protein and plant pathogenesis-related proteins |
本文献已被 ScienceDirect 等数据库收录! |
|