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GAPs for rho-related GTPases |
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| Authors: | Nathalie Lamarche Alan Hall |
| Institution: | MRC Laboratory for molecular cell biology and Department of Biochemistry, University College London, Gower Street, London, UK WC1E 6BT |
| Abstract: | Ras-related GTP-binding proteins (GTPases) of the rbo subfamily play important roles in regulating the organization of the actin cytoskeleton. A large number of multifunctional proteins that can stimulate their intrinsic GTPase activity have been identified. Here, we discuss the nature of such GTPase-activating proteins (GAPs) and their potential importance for cell signalling. |
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