| 白细胞介素18 |
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| 引用本文： | 裴冬生,赵惠仁. 白细胞介素18[J]. 生物化学与生物物理进展, 2000, 27(6): 576-578 |
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| 作者姓名： | 裴冬生 赵惠仁 |
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| 作者单位： | 徐州医学院生物化学与分子生物学研究中心,徐州,221002 |
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| 摘 要： | 白细胞介素-18(IL-18)是新发现的细胞因子，具有多种生物学功能.IL-18能促进外周血单个核细胞产生干扰素-γ(IFN-γ)、IL-2、粒细胞巨噬细胞集落刺激因子(GM-CSF)等细胞因子，增强天然杀伤细胞(NK细胞)的细胞毒作用.IL-18结构上与IL-1相似，而功能更接近IL-12，IL-18与IL-12均能诱导Th1细胞产生IFN-γ，存在协同效应，但它们的作用途径不同.IL-18在抗感染抗肿瘤等方面有着潜在的应用前景，并与自身免疫性疾病的发病密切相关.
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| 关 键 词： | 白细胞介素18，信号转导，自身免疫性疾病，抗肿瘤 |
| 收稿时间： | 2000-06-26 |
| 修稿时间： | : |
Interleukin 18 |
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| PEI Dong-Sheng and ZHAO Hui-Ren. Interleukin 18[J]. Progress In Biochemistry and Biophysics, 2000, 27(6): 576-578 |
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| Authors: | PEI Dong-Sheng and ZHAO Hui-Ren |
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| Affiliation: | Research Center for Biochemistry and Molecular Biology, Xuzhou Medical College,Xuzhou 221002, China;Research Center for Biochemistry and Molecular Biology, Xuzhou Medical College,Xuzhou 221002, China |
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| Abstract: | Interleukin 18 (IL-18) is a recently identified cytokine, originally called interferon gamma inducing factor. Due to its capacity to induce interferon gamma production in Th1 type cells. It has pleiotropic biological functions. IL-18 belongs structurally to the IL-1 cytokine family and shares biological properties with IL-12. Consequently, IL-18 is a potential regulator of antitumor immune response. IL-18 plays an important role in autoimmune disease and endotoxin-induced injury. So, future work will focus on its application as an immunotherapeutic agent for a variety of diseases. |
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| Keywords: | interleukin 18 signal transduction autoimmune disease antitumor |
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