The interaction of aflatoxins with purines and purine nucleosides |
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| Authors: | Janet I Clifford and K R Rees |
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| Institution: | Department of Chemical Pathology, University College Hospital Medical School, London, W.C. 1 |
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| Abstract: | From measurements of thermal hyperchromicity and the behaviour of an aflatoxin-DNA mixture on a Sephadex column it was concluded that aflatoxin B(1) is capable of weak binding to single-stranded DNA. The interactions of the aflatoxins (B(1), G(1) and G(2)) with nucleosides result in difference spectra and suggest that the purine bases and the amino group play a role in the binding of all the aflatoxins to DNA. |
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